Putting proton pump inhibitors into perspective

Proton pump inhibitors and clopidogrel: putting the interaction in perspective.

With this background, the recently postulated drug interaction between proton pump inhibitors (PPIs) and clopidogrel is in a league of its own, spawning a flurry of research and editorializing in a relatively short time, and more is on the way. This attention reflects several factors, including the blockbuster status of the implicated drugs, a theoretically at-risk population in the tens of mil...

Proton Pump Inhibitors: Omeprazole

Oral Proton Pump Inhibitors

There is currently a lack of evidence to suggest superior clinical efficacy of one oral proton pump inhibitor over any other. Proton pump inhibitors display similar doseresponse relationships with similar potencies and efficacies at the equivalent dose. The decision to select one proton pump inhibitor over another is likely to be based on the agents’ licensed indication, patient tolerability an...

Intravenous proton pump inhibitors.

Intravenous (IV) administration of a proton pump inhibitor (PPI) is a faster way to achieve gastric acid suppression than oral administration of the same agent. Peak suppression after IV administration occurs within hours, compared with several days later after oral administration. Thus the IV route of administration offers a faster onset of gastric suppression, achievement of intragastric pH c...

Proton Pump Inhibitors and C. difficile Infection: A Perspective

In the last two decades, epidemiological data from United States national administrative databases and population-based studies have shown a two to six-fold increase in the incidence of Clostridium difficile infection (CDI), especially in the elderly [1-3]. This increase has been observed in diverse settings with C. difficile replacing methicillin resistant Staphylococcus aureus (MRSA) as the m...